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Carcinogenesis In a very lifetime carcinogenicity research carried out in B6C3F1 mice, methylphenidate caused a rise in hepatocellular adenomas, As well as in males only, a rise in hepatoblastomas at a each day dose of close to 60 mg/kg/day. This dose is close to two periods the MRHD of 60 mg/day supplied to kids on mg/m2 basis.your skin, tongue or